Adiponectin gene polymorphisms are associated with increased susceptibility to diabetic peripheral neuropathy

Background: Adiponectin (ADP) polymorphisms associated with diabetes mellitus in several populations. However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). Our study examined the association between ADP-linked SNPs and DPN susceptibility. Methods:...

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Bibliographic Details
Published in:Biomarkers 2015-10, Vol.20 (6-7), p.474-480
Main Authors: Chen, Yao, Wang, Jian, Wang, Lijing, Huang, Peiji, Tan, Zeng-Xian, Liu, Huai-Jun
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Alleles
Base Sequence
Blood Glucose - metabolism
Cholesterol - blood
Diabetic Neuropathies - blood
Diabetic Neuropathies - genetics
diabetic peripheral neuropathy
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Glycated Hemoglobin A - metabolism
haplotype analysis
Haplotypes
Humans
Linkage Disequilibrium
Lipoproteins, LDL - blood
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Sequence Analysis, DNA - methods
single nucleotide polymorphisms
susceptibility
Thyroglobulin - blood
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Summary:Background: Adiponectin (ADP) polymorphisms associated with diabetes mellitus in several populations. However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). Our study examined the association between ADP-linked SNPs and DPN susceptibility. Methods: We randomly recruited 160 diabetes mellitus (DM) patients and 80 healthy individuals. Results: The C allele of rs3821799 increased DPN susceptibility. In normal individuals, GG of rs3774261 carriers had 7.1 times higher DPN susceptibility than AA carriers. The haplotype analyzes indicated CGG might increase DPN susceptibility. Conclusion: Our study demonstrated that ADP gene polymorphisms are associated with the susceptibility to DPN.
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2015.1101784