Role of calcium electrogenesis in apical dendrites: generation of intrinsic oscillations by an axial current

Dendrites are covered with conductances whose function is still mysterious. Using intracellular recording and calcium imaging, we describe an electrogenic band of calcium channels in distal apical dendrites of layer 5 pyramidal neurons (Yuste et al., 1994). We now explore the functional consequences...

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Bibliographic Details
Published in:Journal of computational neuroscience 1999-07, Vol.7 (1), p.41-53
Main Authors: Elaagouby, A, Yuste, R
Format: Article
Language:English
Subjects:
Animals
Buffers
Calcium - physiology
Calcium Channels - physiology
Calcium Channels, L-Type
Calcium Channels, T-Type
Dendrites - chemistry
Dendrites - physiology
Electrophysiology
Fluorescent Dyes
Fura-2
Membrane Potentials - drug effects
Membrane Potentials - physiology
Models, Neurological
Organ Culture Techniques
Periodicity
Potassium Channels - physiology
Pyramidal Cells - chemistry
Pyramidal Cells - physiology
Pyramidal Cells - ultrastructure
Rats
Rats, Sprague-Dawley
Reaction Time - physiology
Somatosensory Cortex - cytology
Somatosensory Cortex - physiology
Tetraethylammonium - pharmacology
Tetrodotoxin - pharmacology
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Summary:Dendrites are covered with conductances whose function is still mysterious. Using intracellular recording and calcium imaging, we describe an electrogenic band of calcium channels in distal apical dendrites of layer 5 pyramidal neurons (Yuste et al., 1994). We now explore the functional consequences of this distal electrogenic area with multicompartmental numerical simulations. A calcium imaging and electrophysiological database from a single neuron, recorded under blocked sodium and potassium conductances, is replicated by simulations having increased dendritic calcium current. In these models a significant axial current flows from the apical dendrite into the somatic region, activating low-threshold calcium channels and generating oscillations similar to those seen in the electrophysiological data. We propose that the distal electrogenic area in apical dendrites serves to inject current into the soma and produce intrinsic oscillatory dynamics.
ISSN:0929-5313
1573-6873
DOI:10.1023/A:1008915510264