The first protocol of stable isotope ratio assessment in tumor tissues based on original research

Thanks to proteomics and metabolomics, for the past several years there has been a real explosion of information on the biology of cancer, which has been achieved by spectroscopic methods, including mass spectrometry. These modern techniques can provide answers to key questions about tissue structur...

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Bibliographic Details
Published in:Polish journal of pathology 2015-09, Vol.66 (3), p.288-295
Main Authors: Taran, Katarzyna, Frączek, Toma, Kamiński, Rafal, Sitkiewicz, Anna, Kobos, Jozef, Paneth, Piotr
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Cancer
Chemical compounds
Child
Child, Preschool
Chromatography
Female
Humans
Infant
Infant, Newborn
Ions
Isotopes
Isotopes - analysis
Male
Mass spectrometry
Mass Spectrometry - methods
Measurement techniques
Medical research
Medicine
Neoplasia
Neoplasms - chemistry
Nobel prizes
Proteomics
Research methodology
Scientific imaging
Signal transduction
Sulfur
Tumors
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Summary:Thanks to proteomics and metabolomics, for the past several years there has been a real explosion of information on the biology of cancer, which has been achieved by spectroscopic methods, including mass spectrometry. These modern techniques can provide answers to key questions about tissue structure and mechanisms of its pathological changes. However, despite the thousands of spectroscopic studies in medicine, there is no consensus on issues ranging from the choice of research tools, acquisition and preparation of test material to the interpretation and validation of the results, which greatly reduces the possibility of transforming the achieved knowledge to progress in the treatment of individual patients. The aim of this study was to verify the utility of isotope ratio mass spectrometry in the evaluation of tumor tissues. Based on experimentation on animal tissues and human neoplasms, the first protocol of stable isotope ratio assessment of carbon and nitrogen isotopes in tumor tissues was established.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2015.54963