Resilience, health, and quality of life among long‐term survivors of hematopoietic cell transplantation

BACKGROUND Low patient‐reported resilience is associated with an ongoing risk of poor health and psychosocial outcomes. Using a large cross‐sectional sample of survivors of hematopoietic cell transplantation (HCT), this study explored associations between patient‐reported resilience, psychological d...

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Bibliographic Details
Published in:Cancer 2015-12, Vol.121 (23), p.4250-4257
Main Authors: Rosenberg, Abby R., Syrjala, Karen L., Martin, Paul J., Flowers, Mary E., Carpenter, Paul A., Salit, Rachel B., Baker, K. Scott, Lee, Stephanie J.
Format: Article
Language:English
Subjects:
Absenteeism
Aged
bone marrow transplantation
Cross-Sectional Studies
Female
Graft vs Host Disease - psychology
Health Surveys
Hematopoietic Stem Cell Transplantation - ethnology
Hematopoietic Stem Cell Transplantation - psychology
Humans
Male
Middle Aged
outcomes studies
psychosocial factors
Quality of Life
resilience
Resilience, Psychological
Survivors - psychology
survivorship
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Summary:BACKGROUND Low patient‐reported resilience is associated with an ongoing risk of poor health and psychosocial outcomes. Using a large cross‐sectional sample of survivors of hematopoietic cell transplantation (HCT), this study explored associations between patient‐reported resilience, psychological distress, posttraumatic growth, and health‐related quality of life. METHODS Between July 1, 2013 and June 30, 2014, the annual Fred Hutchinson Cancer Research Center (FHCRC) posttransplant survivorship survey queried patient‐reported health and functional status and included instruments assessing psychosocial outcomes: the 10‐item Connor‐Davidson Resilience Scale, the Posttraumatic Growth Inventory, the Cancer and Treatment Distress measure, and the 12‐item Medical Outcomes Study Short Form quality‐of‐life scale. Multivariate linear and logistic regression models included demographic and health covariates extracted from the FHCRC research database. RESULTS Among 4643 adult survivors of HCT, 1823 (39%) responded after a single mailing and subsequent reminder letter. The participants' median age was 59 years (interquartile range [IQR], 50‐66 years); 52.5% were male, and most were non‐Hispanic white. The median time since HCT was 9 years (IQR, 3‐18 years). Lower patient‐reported resilience was associated with chronic graft‐versus‐host disease of higher severity, lower performance scores, missing work because of health, and permanent disability (all P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.29651