Unimolecular antiparallel G-quadruplex folding topology of 2'-5'-isoTBA sequences remains unaltered by loop composition

A 2'-5'-linked isoTBA 15 mer sequence with (232) loop composition formed stable antiparallel quadruplex structures similar to the SELEX derived 15 mer TBA sequence with (232) loop composition. A parallel versus antiparallel topology of 3'-5'-G-quadruplexes is largely dictated by...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2015-12, Vol.13 (48), p.11696-11703
Main Authors: Aher, Manisha N, Erande, Namrata D, Fernandes, Moneesha, Kumar, Vaijayanti A
Format: Article
Language:English
Subjects:
DNA - chemistry
G-Quadruplexes
Nucleic Acid Conformation
Protein Multimerization
RNA Folding
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Summary:A 2'-5'-linked isoTBA 15 mer sequence with (232) loop composition formed stable antiparallel quadruplex structures similar to the SELEX derived 15 mer TBA sequence with (232) loop composition. A parallel versus antiparallel topology of 3'-5'-G-quadruplexes is largely dictated by the loop length, and it is known that the truncated loops favour parallel quadruplexes. In contrast to TBA, systematic reduction of the loop length in isoTBA from (232) to (222), (131) or even (111) did not alter the antiparallel topology of the resulting 14 mer, 13 mer and 11 mer G-rich modified isoTBA-like sequences.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01923k