EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys

Investigating the activities of the prefrontal cortex (PFC) in the process of addiction is valuable for understanding the neural mechanism underlying the impairments of the PFC after drug abuse. However, limited data are obtained from primate animals and few studies analyze Electroencephalogram (EEG...

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Bibliographic Details
Published in:Brain research 2005-08, Vol.1053 (1), p.137-145
Main Authors: Liu, Ning, Liu, Yancheng, Fan, Yaodong, Yu, Hualin, Wilson, Fraser A.W., Ma, Yuanye, Hu, Xintian
Format: Article
Language:English
Subjects:
Addiction
Analysis of Variance
Animals
Biological and medical sciences
Drug addictions
Drug Tolerance - physiology
EEG
Electroencephalography - methods
Female
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Macaca mulatta
Medical sciences
Monkey
Morphine
Morphine - administration & dosage
Morphine Dependence - physiopathology
Narcotics - administration & dosage
Prefrontal cortex
Primates
Substance Withdrawal Syndrome - physiopathology
Time Factors
Toxicology
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Summary:Investigating the activities of the prefrontal cortex (PFC) in the process of addiction is valuable for understanding the neural mechanism underlying the impairments of the PFC after drug abuse. However, limited data are obtained from primate animals and few studies analyze Electroencephalogram (EEG) in the gamma band, which plays an important role in cognitive functions. In addition, it is yet unclear whether drug abuse affects the orbitofrontal cortex (OFC) and dorsolateral PFC (DLPFC) – the two most important subregions of the PFC – in similar ways or not. The aim of this study is to address these issues. We recorded EEG in the OFC and DLPFC in three rhesus monkeys. All animals received a course of saline (NaCl 0.9%, 2 ml) injection (5 days) followed by 10 days of morphine injection (every 12 h), and then a further series of saline injection (7 days). A main finding in the present study was that morphine decreased EEG power in all frequency bands in a short period after injection in both the OFC and DLPFC in monkeys. And gamma power decreased not just in a short period after morphine injection but lasted to 12 h after injection. Moreover, we found that although the changes in EEG activities in the OFC and DLPFC at 30–35 min after injection were similar, the DLPFC was more sensitive to the effect of morphine than the OFC.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2005.06.037