Transforming Growth Factor- beta 1 to the Bone

TGF- beta 1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF- beta 1 p...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine reviews 2005-10, Vol.26 (6), p.743-774
Main Authors: Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:TGF- beta 1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF- beta 1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF- beta 1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF- beta 1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF- beta 1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.
ISSN:0163-769X
DOI:10.1210/er.2004-0001