Apolipoprotein E promoter and alpha 2-Macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease

In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha 2-Macroglobin (A2M). There were...

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Bibliographic Details
Published in:Neuroscience letters 1999-07, Vol.269 (3), p.173-177
Main Authors: Chen, L, Baum, L, Ng, H-K, Chan, LYS, Sastre, I, Artiga, MJ, Valdivieso, F, Bullido, MJ, Chiu, HFK, Pang, C-P
Format: Article
Language:English
Subjects:
a2-^AMacroglobulin
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Summary:In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha 2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE member of 4 alleles were significantly increased in AD vs. N ( chi super(2) = 33.3, P < 0.000001). However, neither the -491 A/T ( chi super(2) = 1.13, P = 0.29) nor A2M ( chi super(2) = 0.18, P = 0.67) polymorphism was associated with AD risk, suggesting that these polymorphisms do not represent risk factors for AD in the Chinese population.
ISSN:0304-3940
DOI:10.1016/S0304-3940(99)00421-8