Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we dem...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2005-10, Vol.102 (41), p.14653-14658
Main Authors: Gerard M. J. Beaudoin III, Jeanne M. Sisk, Coulombe, Pierre A., Thompson, Catherine C.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Blotting, Western
Cell lines
Follicles
Genes
Hair
Hair Follicle - physiology
Hair follicles
In Situ Hybridization
Keratinocytes - metabolism
Messenger RNA
Mice
Mice, Knockout
Modulated signal processing
Regeneration - genetics
Regeneration - physiology
Reporter genes
Rodents
Signal Transduction - genetics
Signal Transduction - physiology
Skin
Stem cells
Transcription Factors - metabolism
Transfection
Transgenic animals
Wnt Proteins - metabolism
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Summary:The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in$Hr^{-/-}$mice. We show that expression of Wise, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Wnt function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0507609102