Inhibition of epidermal growth factor-induced interleukin-1β-converting enzyme expression reduces proliferation in the pancreatic carcinoma cell line AsPC-1

It is suggested that interleukin- 1 beta -converting enzyme (ICE) and ICE-related proteases play an important role in programmed cell death (apoptosis). We investigated ICE expression in the human pancreatic carcinoma cell line AsPC -1 after stimulation with epidermal growth factor and found a time...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-09, Vol.59 (18), p.4551-4554
Main Authors: SCHLOSSER, S, GANSAUGE, F, SCHNELLDORFER, T, RAMADANI, M, SCHWARZ, A, BEGER, H.-G, GANSAUGE, S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Gastroenterology. Liver. Pancreas. Abdomen
interleukin 1^b-converting enzyme
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Tumors
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Summary:It is suggested that interleukin- 1 beta -converting enzyme (ICE) and ICE-related proteases play an important role in programmed cell death (apoptosis). We investigated ICE expression in the human pancreatic carcinoma cell line AsPC -1 after stimulation with epidermal growth factor and found a time - dependent expression of active ICE induced by epidermal growth factor. Interestingly, ICE expression does not lead to apoptosis. Cell cycle analyses revealed that acetyl-Tyr-Val -Ala-Asp- chloromethyl -ketone -specific and acetyl -Ala- Ala- Val- Ala-Leu-Leu -Pro- Ala-Val -Leu- Leu-Ala -Leu-Leu -Ala- Pro-Tyr -Val-Ala-Asp- aldehyd- specific cell-permeable inhibitors of ICE significantly reduced the proliferation of AsPC-1 cells, which suggested a positive influence of ICE on the proliferation in human pancreatic carcinoma cells.
ISSN:0008-5472
1538-7445