Nuclear Matrix Protein Expression in Prostate Cancer: Possible Prognostic and Diagnostic Applications

Different lines of evidence suggest that the nuclear matrix (NM), the protein scaffold of the nucleus, represents a functional unit playing a pivotal role in the spatial and temporal coordination of the events of gene activation. Any change in the gene expression pattern, which occurs during carcino...

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Bibliographic Details
Published in:Anticancer research 2005-11, Vol.25 (6B), p.3999-4004
Main Authors: BARBORO, Paola, RUBAGOTTI, Alessandra, BOCCARDO, Francesco, CARNEMOLLA, Barbara, D'ARRIGO, Cristina, PATRONE, Eligio, BALBI, Cecilia
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Humans
Male
Medical sciences
Nephrology. Urinary tract diseases
Nuclear Matrix-Associated Proteins - biosynthesis
Prognosis
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - metabolism
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Different lines of evidence suggest that the nuclear matrix (NM), the protein scaffold of the nucleus, represents a functional unit playing a pivotal role in the spatial and temporal coordination of the events of gene activation. Any change in the gene expression pattern, which occurs during carcinogenesis, may partially depend on an impairment of the regulatory functions of the NM. Therefore, increasing interest has been addressed to the study of NM modifications associated with malignant transformations and to potential clinical applications. Here, recent results on the NM changes in prostate cancer are discussed. Tumor cells are characterized by a more complex NM protein pattern compared to normal tissue: the development of poorly-differentiated tumors is characterized by the expression of proteins that are not present in hyperplastic tissues or in more differentiated tumors. In addition, a few newly-expressed proteins are significantly correlated with the risk of biochemical progression. The potential application of these proteins at the diagnostic and prognostic levels calls for further studies.
ISSN:0250-7005
1791-7530