Protective effect of anti-P-selectin monoclonal antibody in lipopolysaccharide-induced lung hemorrhage

Excessive leukocyte accumulation is involved in the pathogenesis of the sepsis-induced acute lung injury. Selectins are essential to the interaction between leukocytes and endothelial cells. In this report, we investigated the role of selectins in the severe lung injury induced by lipopolysaccharide...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation 1999-10, Vol.23 (5), p.461-470
Main Authors: Ohnishi, M, Imanishi, N, Tojo, S J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
Hemorrhage - chemically induced
Hemorrhage - drug therapy
Hemorrhage - immunology
lipopolysaccharides
Lipopolysaccharides - toxicity
Lung - physiopathology
Male
P-selectin
P-Selectin - immunology
Rats
Rats, Sprague-Dawley
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Excessive leukocyte accumulation is involved in the pathogenesis of the sepsis-induced acute lung injury. Selectins are essential to the interaction between leukocytes and endothelial cells. In this report, we investigated the role of selectins in the severe lung injury induced by lipopolysaccharide (LPS). Significant lung hemorrhage was observed 24 h after the intravenous administration of LPS (1 mg/kg). First, we evaluated the effect of sialyl Lewis X-oligosaccharide (SLeX-OS), a derivative of sialyl Lewis X which is one of the ligands for E-, P- and L-selectins. The treatment with SLeX-OS (26.5 mg/kg iv bolus + 19.8 mg/kg iv infusion) resulted in a decrease of lung hemorrhage by 49.5% (P
ISSN:0360-3997
1573-2576
DOI:10.1023/A:1021917110651