Cytokine signaling: Inhibitors keep cytokines in check

Some members of the CIS/SOCS/JAB/SSI family have been demonstrated to be cytokine-inducible inhibitors of cytokine signaling. Steps have now been made towards clarifying the biological function of two of these proteins, revealing that these inhibitors are essential for the correct maintenance of cyt...

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Bibliographic Details
Published in:Current biology 1999-12, Vol.9 (23), p.R899-R902
Main Authors: Kovanen, Panu E., Leonard, Warren J.
Format: Article
Language:English
Subjects:
CIS protein
Immunology
JAB protein
SOCS protein
SSI protein
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Summary:Some members of the CIS/SOCS/JAB/SSI family have been demonstrated to be cytokine-inducible inhibitors of cytokine signaling. Steps have now been made towards clarifying the biological function of two of these proteins, revealing that these inhibitors are essential for the correct maintenance of cytokine signaling.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(00)80079-2