Impairment of hematopoietic stem cell niches in patients with aplastic anemia

Aplastic anemia (AA) is a serious hematological disorder characterized by pancytopenia and defective bone marrow (BM) microenvironment. Previous investigations have demonstrated that there is a defect of angiogenesis in the BM of patients with AA. However, whether abnormalities of the BM microenviro...

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Bibliographic Details
Published in:International journal of hematology 2015-12, Vol.102 (6), p.645-653
Main Authors: Wu, Liangliang, Mo, Wenjian, Zhang, Yuping, Deng, Hui, Li, Yumiao, Zhou, Ruiqing, Zhang, Lu, Pan, Shiyi, Wang, Shunqing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anemia, Aplastic - pathology
Bone Marrow - blood supply
Bone Marrow - pathology
Bone Marrow Cells - pathology
Child
Female
Hematology
Hematopoiesis
Hematopoietic Stem Cells - pathology
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Middle Aged
Neovascularization, Physiologic
Oncology
Original Article
Young Adult
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Summary:Aplastic anemia (AA) is a serious hematological disorder characterized by pancytopenia and defective bone marrow (BM) microenvironment. Previous investigations have demonstrated that there is a defect of angiogenesis in the BM of patients with AA. However, whether abnormalities of the BM microenvironment, particularly the overall specialization of niches, which have been classified into osteoblastic, vascular, and perivascular niches, are involved in the pathogenesis of AA is unknown. In the present study, 46 patients with AA and 15 controls were selected. The cellular elements of the BM microenvironment, including endosteal, vascular, and perivascular cells, were analyzed by immunohistochemical staining in situ. Patients with AA showed markedly fewer endosteal cells [0.33 vs 3.67 per high-power field (hpf); P  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-015-1881-2