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Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age
The number of elderly patients who undergo hepatectomy for hepatocellular carcinoma (HCC) has been increasing. Therefore, criteria for selection of an appropriate hepatectomy procedure are required. Two hundred and twenty-nine HCC patients undergoing hepatectomy were enrolled in the present study. P...
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| Published in: | Anticancer research 2015-12, Vol.35 (12), p.6855-6860 |
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| Main Authors: | , , , , , , , , , , , |
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| container_end_page | 6860 |
| container_issue | 12 |
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| container_title | Anticancer research |
| container_volume | 35 |
| creator | Sato, Sho Tanaka, Kuniya Nojiri, Kazunori Kumamoto, Takafumi Mori, Ryutaro Taniguchi, Kouichi Matsuyama, Ryusei Takeda, Kazuhisa Ueda, Michio Akiyama, Hirotoshi Taguri, Masataka Endo, Itaru |
| description | The number of elderly patients who undergo hepatectomy for hepatocellular carcinoma (HCC) has been increasing. Therefore, criteria for selection of an appropriate hepatectomy procedure are required.
Two hundred and twenty-nine HCC patients undergoing hepatectomy were enrolled in the present study. Patients were classified into two groups: the elderly group (age ≥75 years, n=34) and the non-elderly group (age |
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Two hundred and twenty-nine HCC patients undergoing hepatectomy were enrolled in the present study. Patients were classified into two groups: the elderly group (age ≥75 years, n=34) and the non-elderly group (age <75 years, n=195). The hepatectomy procedure was selected based on the prognostic score (PS) formula, that includes patient age as a variable.
The incidence of non-anatomical resection was higher (p=0.015) and the weight of resected specimens was lower (p=0.019) in the elderly group than in the non-elderly group. No significant difference was observed in the postoperative complication rate between the two groups. The 5-year survival rates were comparable between the two groups.
Favorable short- and long-term outcomes can be obtained based on cautious selection criteria for hepatectomy procedures, while considering patient age, in the treatment of elderly patients with HCC.</description><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 26637907</identifier><language>eng</language><publisher>Greece</publisher><subject>Age Factors ; Aged ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Female ; Hepatectomy ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Perioperative Period ; Postoperative Complications - etiology ; Survival Analysis</subject><ispartof>Anticancer research, 2015-12, Vol.35 (12), p.6855-6860</ispartof><rights>Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26637907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Sho</creatorcontrib><creatorcontrib>Tanaka, Kuniya</creatorcontrib><creatorcontrib>Nojiri, Kazunori</creatorcontrib><creatorcontrib>Kumamoto, Takafumi</creatorcontrib><creatorcontrib>Mori, Ryutaro</creatorcontrib><creatorcontrib>Taniguchi, Kouichi</creatorcontrib><creatorcontrib>Matsuyama, Ryusei</creatorcontrib><creatorcontrib>Takeda, Kazuhisa</creatorcontrib><creatorcontrib>Ueda, Michio</creatorcontrib><creatorcontrib>Akiyama, Hirotoshi</creatorcontrib><creatorcontrib>Taguri, Masataka</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><title>Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The number of elderly patients who undergo hepatectomy for hepatocellular carcinoma (HCC) has been increasing. Therefore, criteria for selection of an appropriate hepatectomy procedure are required.
Two hundred and twenty-nine HCC patients undergoing hepatectomy were enrolled in the present study. Patients were classified into two groups: the elderly group (age ≥75 years, n=34) and the non-elderly group (age <75 years, n=195). The hepatectomy procedure was selected based on the prognostic score (PS) formula, that includes patient age as a variable.
The incidence of non-anatomical resection was higher (p=0.015) and the weight of resected specimens was lower (p=0.019) in the elderly group than in the non-elderly group. No significant difference was observed in the postoperative complication rate between the two groups. The 5-year survival rates were comparable between the two groups.
Favorable short- and long-term outcomes can be obtained based on cautious selection criteria for hepatectomy procedures, while considering patient age, in the treatment of elderly patients with HCC.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Perioperative Period</subject><subject>Postoperative Complications - etiology</subject><subject>Survival Analysis</subject><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo1kEtPwzAQhC0kREvhLyAfuUSy48QPbqUqFKkSFY9z5MTrEuTEwXYO_fektJx2tZpvRrMXaE6FopkoGZmh6xi_CeFcSXaFZjnnTCgi5ihtYNCpbfAbRGhS63tsfcB_V9-Ac6PTAa90aNredxq3PU5fgNfOQHCHB_wO7oj1-xMy7b474F2YWDMGiPhRRzB4st1NMdAnvNzDDbq02kW4Pc8F-nxaf6w22fb1-WW13GZDTmnKdMms4qVguizzoq6VkkVpaiuZLRTJrTV1YZmlEiwI4LSRhAohJdQAwijDFuj-5DsE_zNCTFXXxmMp3YMfY0VFUXBOFOGT9O4sHesOTDWEttPhUP1_iv0C6DhlbQ</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Sato, Sho</creator><creator>Tanaka, Kuniya</creator><creator>Nojiri, Kazunori</creator><creator>Kumamoto, Takafumi</creator><creator>Mori, Ryutaro</creator><creator>Taniguchi, Kouichi</creator><creator>Matsuyama, Ryusei</creator><creator>Takeda, Kazuhisa</creator><creator>Ueda, Michio</creator><creator>Akiyama, Hirotoshi</creator><creator>Taguri, Masataka</creator><creator>Endo, Itaru</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age</title><author>Sato, Sho ; Tanaka, Kuniya ; Nojiri, Kazunori ; Kumamoto, Takafumi ; Mori, Ryutaro ; Taniguchi, Kouichi ; Matsuyama, Ryusei ; Takeda, Kazuhisa ; Ueda, Michio ; Akiyama, Hirotoshi ; Taguri, Masataka ; Endo, Itaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-a53f96573a5524bb99845dbf83f4902ffdb4f3f18efe7e61c8017788ebee7d9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Perioperative Period</topic><topic>Postoperative Complications - etiology</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Sho</creatorcontrib><creatorcontrib>Tanaka, Kuniya</creatorcontrib><creatorcontrib>Nojiri, Kazunori</creatorcontrib><creatorcontrib>Kumamoto, Takafumi</creatorcontrib><creatorcontrib>Mori, Ryutaro</creatorcontrib><creatorcontrib>Taniguchi, Kouichi</creatorcontrib><creatorcontrib>Matsuyama, Ryusei</creatorcontrib><creatorcontrib>Takeda, Kazuhisa</creatorcontrib><creatorcontrib>Ueda, Michio</creatorcontrib><creatorcontrib>Akiyama, Hirotoshi</creatorcontrib><creatorcontrib>Taguri, Masataka</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Sho</au><au>Tanaka, Kuniya</au><au>Nojiri, Kazunori</au><au>Kumamoto, Takafumi</au><au>Mori, Ryutaro</au><au>Taniguchi, Kouichi</au><au>Matsuyama, Ryusei</au><au>Takeda, Kazuhisa</au><au>Ueda, Michio</au><au>Akiyama, Hirotoshi</au><au>Taguri, Masataka</au><au>Endo, Itaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2015-12</date><risdate>2015</risdate><volume>35</volume><issue>12</issue><spage>6855</spage><epage>6860</epage><pages>6855-6860</pages><eissn>1791-7530</eissn><abstract>The number of elderly patients who undergo hepatectomy for hepatocellular carcinoma (HCC) has been increasing. Therefore, criteria for selection of an appropriate hepatectomy procedure are required.
Two hundred and twenty-nine HCC patients undergoing hepatectomy were enrolled in the present study. Patients were classified into two groups: the elderly group (age ≥75 years, n=34) and the non-elderly group (age <75 years, n=195). The hepatectomy procedure was selected based on the prognostic score (PS) formula, that includes patient age as a variable.
The incidence of non-anatomical resection was higher (p=0.015) and the weight of resected specimens was lower (p=0.019) in the elderly group than in the non-elderly group. No significant difference was observed in the postoperative complication rate between the two groups. The 5-year survival rates were comparable between the two groups.
Favorable short- and long-term outcomes can be obtained based on cautious selection criteria for hepatectomy procedures, while considering patient age, in the treatment of elderly patients with HCC.</abstract><cop>Greece</cop><pmid>26637907</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Anticancer research, 2015-12, Vol.35 (12), p.6855-6860 |
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| subjects | Age Factors Aged Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Female Hepatectomy Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Male Neoplasm Recurrence, Local Neoplasm Staging Perioperative Period Postoperative Complications - etiology Survival Analysis |
| title | Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age |
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