Gender Specific Association between Serum Fibroblast Growth Factor 23/α-Klotho and Coronary Artery and Aortic Valve Calcification

• Published in: Journal of Atherosclerosis and Thrombosis 2015/12/01, Vol.22(12), pp.1338-1346
• Main Authors: Morita, Hideaki, Takeda, Yoshihiro, Fujita, Shu-ichi, Okamoto, Yusuke, Sakane, Kazushi, Teramoto, Kunihiro, Ozeki, Michishige, Tasaki, Ryunosuke, Kizawa, Shun, Sohmiya, Koichi, Hoshiga, Masaaki, Ishizaka, Nobukazu
• Format: Article
• Language: English
• Subjects: Aged; Aortic valve; Aortic Valve - diagnostic imaging; Aortic Valve - pathology; Aortic Valve Stenosis - blood; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - pathology; Calcification; Calcinosis - blood; Calcinosis - diagnostic imaging; Calcinosis - pathology; Coronary artery; Coronary Vessels - pathology; Female; FGF23; Fibroblast Growth Factors - blood; Glucuronidase - blood; Humans; Hypertension - complications; Logistic Models; Male; Middle Aged; Multidetector Computed Tomography; Odds Ratio; Prevalence; Regression Analysis; Risk Factors; Sex Factors; α-Klotho
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.30635

Aim: Fibroblast growth factor 23 (FGF23) and α-Klotho have been recently identified to play a crucial role in calcium/phosphate metabolism. We herein investigated the possible relation between serum FGF23/α-Klotho levels and coronary artery calcification (CAC) and aortic valve calcification (AVC). Methods: Among subjects with diagnosed or suspected coronary artery disease (CAD), CAC and AVC were estimated via the Agatston score of 320-detector computed tomography images, and serum FGF23 and α-Klotho levels were measured. Results: In total, 157 subjects were enrolled (75 women and 82 men). We performed logistic regression using CAC as a dependent variable; the highest FGF23 tertile (＞52.5 pg/mL) was significantly positively associated with CAC with an odds ratio of 6.61 versus the lowest FGF23 tertile (＜35.3 pg/mL) in women after the adjustment for potential confounding variables including age, renal function, hypertension, statin use, diuretic use, and calcium/phosphate metabolism related factors. In addition, the highest α-Klotho tertile (＞561 pg/mL) was significantly associated with AVC with an odds ratio of 6.31 versus the lowest α-Klotho tertile (＜306 pg/mL) in men after adjusting for the same variables. On the other hand, the association between FGF23 and CAC/AVC in men or that between α-Klotho and CAC/AVC in women was nonsignificant. Conclusion: Among subjects with diagnosed or suspected CAD, serum FGF23 was positively associated with CAC in women and serum α-Klotho was positively associated with AVC in men independent of the confounding variables, including the renal function and calcium/phosphate metabolism-related factors.