Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile

Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by qua...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2015-12, Vol.71 (4), p.719-732
Main Authors: Mauriège, P., Joanisse, D. R., CasparBauguil, S., Cartier, A., Lemieux, I., Bergeron, J., Biron, S., Marceau, P., Richard, D.
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipokines - genetics
Adipose Tissue, White - metabolism
Adult
Animal Physiology
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Female
Human Physiology
Humans
Hydrocortisone - biosynthesis
Insulin Resistance
Metabolic Diseases - metabolism
Metabolic Networks and Pathways
Middle Aged
Obesity, Morbid - metabolism
Obesity, Morbid - pathology
Organ Specificity
Original Paper
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcriptome
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Summary:Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS; n  = 25) or without (NDYS; n  = 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women ( p  
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-015-0436-6