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Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile
Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by qua...
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| Published in: | Journal of physiology and biochemistry 2015-12, Vol.71 (4), p.719-732 |
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| container_title | Journal of physiology and biochemistry |
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| creator | Mauriège, P. Joanisse, D. R. CasparBauguil, S. Cartier, A. Lemieux, I. Bergeron, J. Biron, S. Marceau, P. Richard, D. |
| description | Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS;
n
= 25) or without (NDYS;
n
= 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (
p
|
| doi_str_mv | 10.1007/s13105-015-0436-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1744663905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1744663905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-f2cd321e0ecb394c75d412a78362f5fb0510b3781218251a0d9c1dfa784840a03</originalsourceid><addsrcrecordid>eNp9kEtvFDEQhC0EIg_4AVyQj1wm6fZjPHtEEQmRIuUCZ2sebXAyM17cMwn77_Fmkxw5WG2pvqq2S4hPCGcI4M4ZNYKtAMsxuq7qN-IYG-eqxln7ttxRN5WzpjkSJ8x3AEahgvfiSNXGKgv6WNxf0UyS_m4zMcc0yxTkEEOgTPMi2yFuE5NcIvNKvBeZHoo27mTqqCiPaaJZPsblt0z5aaa1-OSw44mWtktj7OU2pxBH-iDehXZk-vg8T8XPy28_Lr5XN7dX1xdfb6reoFmqoPpBKySgvtMb0zs7GFSta3Stgg0dWIROuwYVNspiC8OmxyEUwDQGWtCn4ssht-z9U569-ClyT-PYzpRW9uiMqWu9AVtQPKB9TsyZgt_mOLV55xH8vmN_6NiXjv2-Y18Xz-fn-LWbaHh1vJRaAHUAuEjzL8r-Lq15Ll_-T-o_gDSH4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1744663905</pqid></control><display><type>article</type><title>Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile</title><source>Springer Link</source><creator>Mauriège, P. ; Joanisse, D. R. ; CasparBauguil, S. ; Cartier, A. ; Lemieux, I. ; Bergeron, J. ; Biron, S. ; Marceau, P. ; Richard, D.</creator><creatorcontrib>Mauriège, P. ; Joanisse, D. R. ; CasparBauguil, S. ; Cartier, A. ; Lemieux, I. ; Bergeron, J. ; Biron, S. ; Marceau, P. ; Richard, D.</creatorcontrib><description>Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS;
n
= 25) or without (NDYS;
n
= 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (
p
< 0.05). Among enzymes involved in fatty acid metabolism and local cortisol production, phosphodiesterase-3B expression was lower in SCABD and MES fat, while 11β-hydroxysteroid dehydrogenase type 1 mRNA levels were higher in visceral depots of DYS women (
p
< 0.05). Regarding vascular homeostasis and inflammation, plasminogen activator inhibitor-1 and interleukin-6 mRNA levels were higher in OME fat, while adiponectin expression was lower in SCABD and OME ATs of DYS women (
p
< 0.05). Finally, HOMA-IR was positively associated with SCABD AT IL6 mRNA, only in DYS women (
r
= 0.47;
p
< 0.05). In conclusion, although metabolic and secretory characteristics of all depots vary with subjects’ metabolic profile, we find little evidence for a protective role of SCABD AT and no evidence for a further deleterious role of MES fat in DYS vs. NDYS severely obese women. Regional variation in the overall gene expression revealed that OME and MES fat were more closely related to each other in DYS women, while SCABD and MES depots showed greater resemblance in NDYS women.</description><identifier>ISSN: 1138-7548</identifier><identifier>EISSN: 1877-8755</identifier><identifier>DOI: 10.1007/s13105-015-0436-6</identifier><identifier>PMID: 26452503</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adipokines - blood ; Adipokines - genetics ; Adipose Tissue, White - metabolism ; Adult ; Animal Physiology ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Female ; Human Physiology ; Humans ; Hydrocortisone - biosynthesis ; Insulin Resistance ; Metabolic Diseases - metabolism ; Metabolic Networks and Pathways ; Middle Aged ; Obesity, Morbid - metabolism ; Obesity, Morbid - pathology ; Organ Specificity ; Original Paper ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcriptome</subject><ispartof>Journal of physiology and biochemistry, 2015-12, Vol.71 (4), p.719-732</ispartof><rights>University of Navarra 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-f2cd321e0ecb394c75d412a78362f5fb0510b3781218251a0d9c1dfa784840a03</citedby><cites>FETCH-LOGICAL-c414t-f2cd321e0ecb394c75d412a78362f5fb0510b3781218251a0d9c1dfa784840a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26452503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mauriège, P.</creatorcontrib><creatorcontrib>Joanisse, D. R.</creatorcontrib><creatorcontrib>CasparBauguil, S.</creatorcontrib><creatorcontrib>Cartier, A.</creatorcontrib><creatorcontrib>Lemieux, I.</creatorcontrib><creatorcontrib>Bergeron, J.</creatorcontrib><creatorcontrib>Biron, S.</creatorcontrib><creatorcontrib>Marceau, P.</creatorcontrib><creatorcontrib>Richard, D.</creatorcontrib><title>Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile</title><title>Journal of physiology and biochemistry</title><addtitle>J Physiol Biochem</addtitle><addtitle>J Physiol Biochem</addtitle><description>Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS;
n
= 25) or without (NDYS;
n
= 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (
p
< 0.05). Among enzymes involved in fatty acid metabolism and local cortisol production, phosphodiesterase-3B expression was lower in SCABD and MES fat, while 11β-hydroxysteroid dehydrogenase type 1 mRNA levels were higher in visceral depots of DYS women (
p
< 0.05). Regarding vascular homeostasis and inflammation, plasminogen activator inhibitor-1 and interleukin-6 mRNA levels were higher in OME fat, while adiponectin expression was lower in SCABD and OME ATs of DYS women (
p
< 0.05). Finally, HOMA-IR was positively associated with SCABD AT IL6 mRNA, only in DYS women (
r
= 0.47;
p
< 0.05). In conclusion, although metabolic and secretory characteristics of all depots vary with subjects’ metabolic profile, we find little evidence for a protective role of SCABD AT and no evidence for a further deleterious role of MES fat in DYS vs. NDYS severely obese women. Regional variation in the overall gene expression revealed that OME and MES fat were more closely related to each other in DYS women, while SCABD and MES depots showed greater resemblance in NDYS women.</description><subject>Adipokines - blood</subject><subject>Adipokines - genetics</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Adult</subject><subject>Animal Physiology</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hydrocortisone - biosynthesis</subject><subject>Insulin Resistance</subject><subject>Metabolic Diseases - metabolism</subject><subject>Metabolic Networks and Pathways</subject><subject>Middle Aged</subject><subject>Obesity, Morbid - metabolism</subject><subject>Obesity, Morbid - pathology</subject><subject>Organ Specificity</subject><subject>Original Paper</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcriptome</subject><issn>1138-7548</issn><issn>1877-8755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kEtvFDEQhC0EIg_4AVyQj1wm6fZjPHtEEQmRIuUCZ2sebXAyM17cMwn77_Fmkxw5WG2pvqq2S4hPCGcI4M4ZNYKtAMsxuq7qN-IYG-eqxln7ttxRN5WzpjkSJ8x3AEahgvfiSNXGKgv6WNxf0UyS_m4zMcc0yxTkEEOgTPMi2yFuE5NcIvNKvBeZHoo27mTqqCiPaaJZPsblt0z5aaa1-OSw44mWtktj7OU2pxBH-iDehXZk-vg8T8XPy28_Lr5XN7dX1xdfb6reoFmqoPpBKySgvtMb0zs7GFSta3Stgg0dWIROuwYVNspiC8OmxyEUwDQGWtCn4ssht-z9U569-ClyT-PYzpRW9uiMqWu9AVtQPKB9TsyZgt_mOLV55xH8vmN_6NiXjv2-Y18Xz-fn-LWbaHh1vJRaAHUAuEjzL8r-Lq15Ll_-T-o_gDSH4w</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Mauriège, P.</creator><creator>Joanisse, D. R.</creator><creator>CasparBauguil, S.</creator><creator>Cartier, A.</creator><creator>Lemieux, I.</creator><creator>Bergeron, J.</creator><creator>Biron, S.</creator><creator>Marceau, P.</creator><creator>Richard, D.</creator><general>Springer Netherlands</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile</title><author>Mauriège, P. ; Joanisse, D. R. ; CasparBauguil, S. ; Cartier, A. ; Lemieux, I. ; Bergeron, J. ; Biron, S. ; Marceau, P. ; Richard, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-f2cd321e0ecb394c75d412a78362f5fb0510b3781218251a0d9c1dfa784840a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipokines - blood</topic><topic>Adipokines - genetics</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Adult</topic><topic>Animal Physiology</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hydrocortisone - biosynthesis</topic><topic>Insulin Resistance</topic><topic>Metabolic Diseases - metabolism</topic><topic>Metabolic Networks and Pathways</topic><topic>Middle Aged</topic><topic>Obesity, Morbid - metabolism</topic><topic>Obesity, Morbid - pathology</topic><topic>Organ Specificity</topic><topic>Original Paper</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcriptome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauriège, P.</creatorcontrib><creatorcontrib>Joanisse, D. R.</creatorcontrib><creatorcontrib>CasparBauguil, S.</creatorcontrib><creatorcontrib>Cartier, A.</creatorcontrib><creatorcontrib>Lemieux, I.</creatorcontrib><creatorcontrib>Bergeron, J.</creatorcontrib><creatorcontrib>Biron, S.</creatorcontrib><creatorcontrib>Marceau, P.</creatorcontrib><creatorcontrib>Richard, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauriège, P.</au><au>Joanisse, D. R.</au><au>CasparBauguil, S.</au><au>Cartier, A.</au><au>Lemieux, I.</au><au>Bergeron, J.</au><au>Biron, S.</au><au>Marceau, P.</au><au>Richard, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile</atitle><jtitle>Journal of physiology and biochemistry</jtitle><stitle>J Physiol Biochem</stitle><addtitle>J Physiol Biochem</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>71</volume><issue>4</issue><spage>719</spage><epage>732</epage><pages>719-732</pages><issn>1138-7548</issn><eissn>1877-8755</eissn><abstract>Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS;
n
= 25) or without (NDYS;
n
= 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (
p
< 0.05). Among enzymes involved in fatty acid metabolism and local cortisol production, phosphodiesterase-3B expression was lower in SCABD and MES fat, while 11β-hydroxysteroid dehydrogenase type 1 mRNA levels were higher in visceral depots of DYS women (
p
< 0.05). Regarding vascular homeostasis and inflammation, plasminogen activator inhibitor-1 and interleukin-6 mRNA levels were higher in OME fat, while adiponectin expression was lower in SCABD and OME ATs of DYS women (
p
< 0.05). Finally, HOMA-IR was positively associated with SCABD AT IL6 mRNA, only in DYS women (
r
= 0.47;
p
< 0.05). In conclusion, although metabolic and secretory characteristics of all depots vary with subjects’ metabolic profile, we find little evidence for a protective role of SCABD AT and no evidence for a further deleterious role of MES fat in DYS vs. NDYS severely obese women. Regional variation in the overall gene expression revealed that OME and MES fat were more closely related to each other in DYS women, while SCABD and MES depots showed greater resemblance in NDYS women.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26452503</pmid><doi>10.1007/s13105-015-0436-6</doi><tpages>14</tpages></addata></record> |
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| subjects | Adipokines - blood Adipokines - genetics Adipose Tissue, White - metabolism Adult Animal Physiology Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Female Human Physiology Humans Hydrocortisone - biosynthesis Insulin Resistance Metabolic Diseases - metabolism Metabolic Networks and Pathways Middle Aged Obesity, Morbid - metabolism Obesity, Morbid - pathology Organ Specificity Original Paper RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptome |
| title | Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile |
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