Synthesis of 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline

The synthesis of 6- and 7-propargyloxy-4-anilinoquinazolines as probes for tyrosine kinases is described. The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy deriva...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2011-03, Vol.52 (10), p.1053-1056
Main Authors: Pham, Helen Trinh, Hanson, Robert N., Olmsted, Sandra L., Kozhushnyan, Anton, Visentin, Adam, Weglinsky, Paul J., Massero, Chris, Bailey, Kristen
Format: Article
Language:English
Subjects:
Anilinoquinazoline
Bifunctional derivatives
Derivatives
Synthesis (chemistry)
Tetrahedrons
Tyrosine kinase inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis of 6- and 7-propargyloxy-4-anilinoquinazolines as probes for tyrosine kinases is described. The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy derivative and analogous 7-propargyloxy containing compounds is also described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.11.107