Synthesis of 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline

The synthesis of 6- and 7-propargyloxy-4-anilinoquinazolines as probes for tyrosine kinases is described. The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy deriva...

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Published in:Tetrahedron letters 2011-03, Vol.52 (10), p.1053-1056
Main Authors: Pham, Helen Trinh, Hanson, Robert N., Olmsted, Sandra L., Kozhushnyan, Anton, Visentin, Adam, Weglinsky, Paul J., Massero, Chris, Bailey, Kristen
Format: Article
Language:English
Subjects:
Anilinoquinazoline
Bifunctional derivatives
Derivatives
Synthesis (chemistry)
Tetrahedrons
Tyrosine kinase inhibitors
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creator Pham, Helen Trinh
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description The synthesis of 6- and 7-propargyloxy-4-anilinoquinazolines as probes for tyrosine kinases is described. The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy derivative and analogous 7-propargyloxy containing compounds is also described.
doi_str_mv 10.1016/j.tetlet.2010.11.107
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subjects Anilinoquinazoline
Bifunctional derivatives
Derivatives
Synthesis (chemistry)
Tetrahedrons
Tyrosine kinase inhibitors
title Synthesis of 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline
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