Efficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor

Generation and subsequent electrophilic reaction of a Boc-protected azabicyclo[2.2.1]heptane anion led to efficient preparation of the potent GlyT1 uptake inhibitor 1 in five steps and 26% overall yield. An efficient synthetic route based on generation and subsequent electrophilic reaction of a Boc-...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2010-12, Vol.51 (51), p.6741-6744
Main Authors: Xiong, Hui, Frietze, William, Andisik, Donald W., Ernst, Glen E., Palmer, William E., Hinkley, Lindsay, Varnes, Jeffrey G., Albert, Jeffrey S., Veale, Chris A.
Format: Article
Language:English
Subjects:
Anions
Heptanes
Inhibitors
Synthesis (chemistry)
Tetrahedrons
Uptakes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Generation and subsequent electrophilic reaction of a Boc-protected azabicyclo[2.2.1]heptane anion led to efficient preparation of the potent GlyT1 uptake inhibitor 1 in five steps and 26% overall yield. An efficient synthetic route based on generation and subsequent electrophilic reaction of a Boc-protected azabicyclo[2.2.1]heptane anion to prepare a potent GlyT1 uptake inhibitor ( 1) is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.10.079