Novel and highly efficient one pot protocol for the synthesis of diversely functionalized triarylmethanes

[Display omitted] An efficient, convenient, and novel one pot approach is described for the synthesis of triarylmethanes by in situ oxidation of benzylalcohols followed by the Friedel–Crafts alkylation of di/trimethoxybenzenes in the presence of BF3·OEt2. The generality of the present method is stre...

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Bibliographic Details
Published in:Tetrahedron letters 2015-02, Vol.56 (6), p.766-771
Main Authors: Babu, B. Madhu, Thakur, Pramod B., Bangade, Vikas M., Meshram, H.M.
Format: Article
Language:English
Subjects:
Aliphatic compounds
Alkylation
Aromatic compounds
BF3·OEt2
Friedel–Crafts reaction
Lewis acid
Oxidation
Reaction time
Screening
Synthesis (chemistry)
Tetrahedrons
Triarylmethanes
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Summary:[Display omitted] An efficient, convenient, and novel one pot approach is described for the synthesis of triarylmethanes by in situ oxidation of benzylalcohols followed by the Friedel–Crafts alkylation of di/trimethoxybenzenes in the presence of BF3·OEt2. The generality of the present method is strengthened by screening a variety of aromatic, aliphatic, and heteroaromatic alcohols with methoxy arenes. Shorter reaction time, mild reaction condition, good yields, and wide scope of substrates are the significant features of this protocol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.11.139