Sodium chloride: a proficient additive for the synthesis of pyridine derivatives in aqueous medium

• Published in: Tetrahedron letters 2014-12, Vol.55 (50), p.6939-6942
• Main Authors: Gujar, Jitendra B., Chaudhari, Mahendra A., Kawade, Deepak S., Shingare, Murlidhar S.
• Format: Article
• Language: English
• Subjects: Additives; Aqueous medium; Construction; Derivatives; Hydrophobic effect; Pyridines; Salting effect; Sodium chloride; Strategy; Synthesis (chemistry); Tetrahedrons; Ultrasound
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2014.10.125

[Display omitted] In the present work, a facile and convenient synthesis of substituted pyridines has been developed via a one-pot multicomponent reaction of easily available aromatic aldehydes, malononitrile and thiophenol under aqueous media and in the presence of NaCl as mild conditions. A series of functionalized pyridines were thus obtained by this multicomponent reaction, in which four new bonds were formed. Particularly valuable features of this protocol including mild conditions, simple execution, broad substrate scope and good yields of products make it an efficient and promising synthetic strategy to build pyridine skeleton. A facile and convenient synthesis of substituted pyridine derivatives catalysed by NaCl in the presence aqueous media under reflux and ultrasound irradiation has been developed via a one-pot multicomponent reaction, in which four new bonds were formed. Particularly valuable features of this protocol including mild conditions, simple execution, broad substrate scope and good yields of products make it an efficient and promising synthetic strategy to build pyridine skeleton.