Dysotriflorins A–M, triterpenoids from Dysoxylum densiflorum

Thirteen new triterpenoids, dysotriflorins A–M (1–13), were isolated from Dysoxylum densiflorum barks, and their structures were elucidated on the basis of NMR spectroscopic data and X-ray crystallography. Dysotriflorins A, B, and K–M (1, 2, and 11–13) were concluded to be unique 13,17-secodammarane...

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Bibliographic Details
Published in:Tetrahedron 2014-12, Vol.70 (51), p.9661-9667
Main Authors: Nugroho, Alfarius E., Momota, Takanori, Sugiura, Rio, Hanzawa, Marina, Yajima, Erika, Nagakura, Yuta, Yasuda, Naoki, Hirasawa, Yusuke, Wong, Chin Piow, Kaneda, Toshio, Hadi, A. Hamid A., Fukaya, Haruhiko, Morita, Hiroshi
Format: Article
Language:English
Subjects:
13,17-Secodammarane
Bark
Biotechnology
Cancer
Crystallography
Cytotoxicity
Dammarane
Dysotriflorin
Dysoxylum densiflorum
In vitro testing
Spectroscopy
Tetrahedrons
Triterpenoid
X-rays
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Summary:Thirteen new triterpenoids, dysotriflorins A–M (1–13), were isolated from Dysoxylum densiflorum barks, and their structures were elucidated on the basis of NMR spectroscopic data and X-ray crystallography. Dysotriflorins A, B, and K–M (1, 2, and 11–13) were concluded to be unique 13,17-secodammarane triterpenoids, and dysotriflorins C–J (3–10) to be dammarane triterpenoids. Dysotriflorins showed in vitro cytotoxic activity against several cancer cell lines. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.10.070