An efficient and simple Morita-Baylis-Hillman reaction based on the N-methylpyrrolidine-Ba(OH) sub(2 catalytic system)

By using of precise catalytic amount of N-methylpyrrolidine (5 mol %) and Ba(OH) sub(2 (1.5 mol %) in H) sub(2)O/CH sub(3OH 5/1 or CH) sub(3)OH/CH sub(2Cl) sub(2) 3/1 solvent mixtures at T=0 [deg]C a Morita-Baylis-Hillman derivatives could be obtained in good to excellent yield from 2-cyclopenten-1-...

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Bibliographic Details
Published in:Tetrahedron 2011-04, Vol.67 (14), p.2562-2569
Main Authors: Guerra, Krassimira P, Afonso, Carlos AM
Format: Article
Language:English
Subjects:
Aromatic compounds
Catalysis
Catalysts
Derivatives
Formaldehyde
Reaction time
Solvents
Tetrahedrons
Online Access:Get full text
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Summary:By using of precise catalytic amount of N-methylpyrrolidine (5 mol %) and Ba(OH) sub(2 (1.5 mol %) in H) sub(2)O/CH sub(3OH 5/1 or CH) sub(3)OH/CH sub(2Cl) sub(2) 3/1 solvent mixtures at T=0 [deg]C a Morita-Baylis-Hillman derivatives could be obtained in good to excellent yield from 2-cyclopenten-1-one, 2-cyclohexen-1-one and formaldehyde and diverse aryl aldehydes after suitable reaction time.
ISSN:0040-4020
DOI:10.1016/j.tet.2011.02.020