A concise synthesis of HIV integrase inhibitors bearing the dipyridone acid motif

An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds.

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Bibliographic Details
Published in:Tetrahedron letters 2011-01, Vol.52 (4), p.512-514
Main Authors: Platts, Michelle Y., Barber, Christopher G., Chiva, Jean-Yves, Eastwood, Rachel L., Fenwick, David R., Paradowski, Kerry A., Blakemore, David C.
Format: Article
Language:English
Subjects:
Antiviral agents
Bearing
Dipyridone acid
Formations
Heterocycles
HIV
Inhibitors
Integrase
Ring-closure
Synthesis (chemistry)
Tetrahedrons
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Description
Summary:An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.11.112