A novel one-pot synthesis of secondary alcohols from esters

Alkylation or vinylation by using organometallic reagents after partial reduction of carboxylic esters with LDBBA gave secondary alcohols, also involving allyl alcohols, without any isolation of intermediates in good yield (54-78%).

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Bibliographic Details
Published in:Tetrahedron letters 2011-04, Vol.52 (14), p.1718-1720
Main Authors: Chae, Min Jung, Jeon, Ah Ram, Park, Jae Kyo, An, Duk Keun
Format: Article
Language:English
Subjects:
Alcohols
Alkylation
Chemistry
Esters
Exact sciences and technology
Kinetics and mechanisms
Metalorganic compounds
Organic chemistry
Reactivity and mechanisms
Reduction
Synthesis (chemistry)
Tetrahedrons
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Description
Summary:Alkylation or vinylation by using organometallic reagents after partial reduction of carboxylic esters with LDBBA gave secondary alcohols, also involving allyl alcohols, without any isolation of intermediates in good yield (54-78%).
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.02.005