Solvent-free sonochemical one-pot three-component synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

A rapid and efficient one-pot three-component protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones 4 and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones 6 has been developed by domino coupling of phthalhydrazide, 1,3-diketones, and aldehydes under solvent-free conditions at 80°C as w...

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Bibliographic Details
Published in:Tetrahedron letters 2011-12, Vol.52 (52), p.7195-7198
Main Authors: Shukla, Gaurav, Verma, Rajiv K., Verma, Girijesh K., Singh, Maya Shankar
Format: Article
Language:English
Subjects:
(S)-Camphorsulfonic acid
Aldehydes
Chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Indazolo[2,1-b]phthalazine-1,6,11-triones
Irradiation
Joining
One-pot three-component reaction
Organic chemistry
Physical chemistry of induced reactions (with radiations, particles and ultrasonics)
Preparations and properties
Pyrazolo[1,2-b]phthalazine-5,10-diones
Solvent-free conditions
Synthesis (chemistry)
Tetrahedrons
Ultrasonic chemistry
Ultrasound
Ultrasound irradiation
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Summary:A rapid and efficient one-pot three-component protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-triones 4 and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones 6 has been developed by domino coupling of phthalhydrazide, 1,3-diketones, and aldehydes under solvent-free conditions at 80°C as well as under solvent-free ultrasound irradiation at room temperature promoted by (S)-camphorsulfonic acid.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.10.136