Ligand-free copper(0) catalyzed direct C–H arylation of 1,2,4-triazoles and 1,3,4-oxadiazoles with aryl iodides in PEG-400

[Display omitted] A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction...

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Bibliographic Details
Published in:Tetrahedron letters 2015-01, Vol.56 (5), p.690-692
Main Authors: Tadikonda, Ramu, Nakka, Mangarao, Rayavarapu, Srinuvasarao, Kalidindi, Siva Prasada Kumar, Vidavalur, Siddaiah
Format: Article
Language:English
Subjects:
2,5-Diaryl-1,3,4-oxadiazole
3,4,5-Triaryl-1,2,4-triazole
Aromatic compounds
Arylation
Chelating
Copper
Copper powder
Coupling reaction
Iodides
Ligand-free
Ligands
Synthesis
Tetrahedrons
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Summary:[Display omitted] A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction medium. The procedure is experimentally simple and free from addition of external chelating ligands or co-catalysts.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.12.064