A convenient hydroiodination of alkynes using I sub(2)/PPh sub(3)/H sub(2)O and its application to the one-pot synthesis of trisubstituted alkenes via iodoalkenes using Pd-catalyzed cross-coupling reactions

A facile hydroiodination of alkynes using readily-available reagents such as I sub(2), PPh sub(3), and H sub(2)O has been developed. This is extended to the one-pot synthesis of trisubstituted alkenes from alkynes via iodoalkenes using Pd-catalyzed cross-coupling and related methods such as the Suzu...

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Bibliographic Details
Published in:Tetrahedron letters 2014-12, Vol.55 (50), p.6779-6783
Main Authors: Kawaguchi, Shin-ichi, Gonda, Yuhei, Masuno, Haruna, Vu, Hue Thi, Yamaguchi, Kotaro, Shinohara, Hiroyuki, Sonoda, Motohiro, Ogawa, Akiya
Format: Article
Language:English
Subjects:
Alkenes
Alkynes
Chemical reactions
Cross coupling
Palladium
Synthesis (chemistry)
Tetrahedrons
Online Access:Get full text
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Summary:A facile hydroiodination of alkynes using readily-available reagents such as I sub(2), PPh sub(3), and H sub(2)O has been developed. This is extended to the one-pot synthesis of trisubstituted alkenes from alkynes via iodoalkenes using Pd-catalyzed cross-coupling and related methods such as the Suzuki-Miyaura cross-coupling, Sonogashira cross-coupling reaction, and Mizoroki-Heck reaction.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2014.10.039