A novel and facile synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from benzylic alcohols through a one-pot, three-component system

[Display omitted] A simple one-pot procedure has been developed to efficiently prepare 1,4,5-trisubstituted 1,2,3-triazoles from benzylic alcohols. The presence of diphenylphosphoryl azide (DPPA) and active ketones allows for an azide–enolate [3+2] cycloaddition by use of DBU.

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Bibliographic Details
Published in:Tetrahedron letters 2015-01, Vol.56 (3), p.514-516
Main Authors: González-Calderón, Davir, Santillán-Iniesta, Itzel, González-González, Carlos A., Fuentes-Benítes, Aydeé, González-Romero, Carlos
Format: Article
Language:English
Subjects:
Alcohols
Azide–enolate cycloaddition
Benzylic alcohols
Cycloaddition
Diphenylphosphoryl azide
Ketones
Synthesis (chemistry)
Tetrahedrons
Triazoles
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Summary:[Display omitted] A simple one-pot procedure has been developed to efficiently prepare 1,4,5-trisubstituted 1,2,3-triazoles from benzylic alcohols. The presence of diphenylphosphoryl azide (DPPA) and active ketones allows for an azide–enolate [3+2] cycloaddition by use of DBU.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.12.019