Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389

Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B ( 1 and 2, Fig. 1) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylated derivative of prugosene A1, which was produced...

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Bibliographic Details
Published in:Tetrahedron 2011-09, Vol.67 (35), p.6582-6586
Main Authors: Mori, Mihoko, Morimoto, Hiromi, Kim, Yong-Pil, Ui, Hideaki, Nonaka, Kenichi, Masuma, Rokuro, Sakamoto, Kimitoshi, Kita, Kiyoshi, Tomoda, Hiroshi, Shiomi, Kazuro, Ōmura, Satoshi
Format: Article
Language:English
Subjects:
Broths
Chemistry
Culture
Derivatives
Electron transport enzyme inhibitor
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Inhibitors
NADH-fumarate reductase
Organic chemistry
Penicillium
Preparations and properties
Reductases
Screening
Tetrahedrons
Ukulactone
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Summary:Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B ( 1 and 2, Fig. 1) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylated derivative of prugosene A1, which was produced by Penicillium rugulosum and NOESY experiment revealed ukulactone B was a stereoisomer of ukulactone A. Ukulactone A showed potent inhibitory activity against NADH-fumarate reductase of the roundworm Ascaris suum in vitro. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.05.090