Organocatalytic enantioselective multicomponent cascade reaction: facile access to tetrahydropyridines with C3 all-carbon quaternary stereocenters

A novel organocatalytic asymmetric multicomponent cascade reaction for the synthesis of valuable tetrahydropyridines has been developed. The merit of this cascade process is highlighted by its high efficiency of producing five new bonds and an all-carbon quaternary stereocenter in one operation, whi...

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Bibliographic Details
Published in:Tetrahedron 2011-05, Vol.67 (18), p.3273-3277
Main Authors: Yu, De-Feng, Wang, Yao, Xu, Peng-Fei
Format: Article
Language:English
Subjects:
Asymmetry
Cascade chemical reactions
Cascade reactions
Cascades
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Multicomponent
Organic chemistry
Organocatalysis
Preparations and properties
Quaternary stereocenters
Strategy
Synthesis (chemistry)
Tetrahedrons
Tetrahydropyridines
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Summary:A novel organocatalytic asymmetric multicomponent cascade reaction for the synthesis of valuable tetrahydropyridines has been developed. The merit of this cascade process is highlighted by its high efficiency of producing five new bonds and an all-carbon quaternary stereocenter in one operation, which otherwise is a big challenge to access by traditional strategies. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.02.047