An expeditious approach to 1-(isoquinolin-1-yl)guanidines via a three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide

A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide. The preliminary biological screens of these isoquinoline library members have been evaluated, which show...

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Bibliographic Details
Published in:Tetrahedron 2011-08, Vol.67 (33), p.5871-5877
Main Authors: Wang, Huanhuan, Ye, Shengqing, Jin, Hanpeng, Liu, Jianping, Wu, Jie
Format: Article
Language:English
Subjects:
1-(Isoquinolin-1-yl)guanidine
2-Alkynylbenzaldehyde
Biological
Carbodiimide
Carbodiimides
Chemistry
Construction
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Inhibitors
Libraries
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
Screens
Silver
Silver triflate
Sulfonohydrazide
Tetrahedrons
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Summary:A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide. The preliminary biological screens of these isoquinoline library members have been evaluated, which show promising results as PTP1B inhibitor and HCT-116 inhibitor. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.06.056