Efficient synthesis of new 3-heteroaryl-1-functionalized 1H-indazoles

The efficient synthesis of novel 3-heteroaryl N-1-functionalized indazoles, via palladium cross-coupling reactions of ethyl (3-iodo-1H-indazol-1-yl)acetate with 2- and 3-pyrrolylboronic acids, 2-, 4- and 5-thiazolylstannanes, and other heteroarylmetallated derivatives are reported.

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Bibliographic Details
Published in:Tetrahedron 2011-01, Vol.67 (1), p.100-105
Main Authors: Fraile, Alberto, Martín, M. Rosario, García Ruano, José Luis, Díaz, Juan Antonio, Arranz, Esther
Format: Article
Language:English
Subjects:
acetates
azoles
Chemical reactions
Chemistry
Derivatives
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Palladium
Preparations and properties
synthesis
Synthesis (chemistry)
Tetrahedrons
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Description
Summary:The efficient synthesis of novel 3-heteroaryl N-1-functionalized indazoles, via palladium cross-coupling reactions of ethyl (3-iodo-1H-indazol-1-yl)acetate with 2- and 3-pyrrolylboronic acids, 2-, 4- and 5-thiazolylstannanes, and other heteroarylmetallated derivatives are reported.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2010.11.021