Cd(II)-terpyridine-based complex as a ratiometric fluorescent probe for pyrophosphate detection in solution and as an imaging agent in living cells

The terpyridine anthracene ligand was synthesized and characterized. is a ratiometric fluorescent probe for Cd(2+) with a recognition mechanism based on intramolecular charge transfer (ICT). An complex was isolated, and its structure was established using single-crystal XRD. The complex was able to...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2015-01, Vol.44 (3), p.1358-1365
Main Authors: Jiao, Shu-Yan, Li, Kun, Zhang, Wei, Liu, Yan-Hong, Huang, Zeng, Yu, Xiao-Qi
Format: Article
Language:English
Subjects:
Animals
Cadmium - chemistry
Cell Line
Channels
Charge transfer
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - metabolism
Crystallography, X-Ray
Diphosphates - analysis
Emission
Fluorescence
Fluorescent Dyes - chemistry
Imaging
Ligands
Mice
Microscopy, Confocal
Molecular Conformation
Pyridines - chemistry
Recognition
Single crystals
Solutions - chemistry
Spectrometry, Fluorescence
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Summary:The terpyridine anthracene ligand was synthesized and characterized. is a ratiometric fluorescent probe for Cd(2+) with a recognition mechanism based on intramolecular charge transfer (ICT). An complex was isolated, and its structure was established using single-crystal XRD. The complex was able to serve as a novel reversible chemosensing ensemble to allow ratiometric response to pyrophosphate (PPi) in aqueous media. Moreover, the fluorescence imaging in living cells from these two emission channels suggested that was a ratiometric probe for Cd(2+), and the in situ generated complex was also a ratiometric ensemble for PPi detection in living cells.
ISSN:1477-9226
1477-9234
DOI:10.1039/c4dt03022b