2,3,6-Trideoxy sugar nucleotides: synthesis and stability

The synthesis and characterization of highly challenging 2,3,6-trideoxy sugar nucleotides were described for the first time. The study of their hydrolysis kinetics in aqueous buffers provided insight into their application as glycosyl donors.

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Bibliographic Details
Published in:Tetrahedron letters 2011-11, Vol.52 (44), p.5799-5801
Main Authors: Wu, Mingxuan, Meng, Qingqing, Ge, Min, Bai, Linquan, Zhou, Huchen
Format: Article
Language:English
Subjects:
2,3,6-Trideoxy
Buffers
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Hydrolysis
Kinetics and mechanisms
Nucleosides, nucleotides and oligonucleotides
Nucleotides
Organic chemistry
Preparations and properties
Reactivity and mechanisms
Stability
Sugar nucleotides
Sugars
Synthesis
Synthesis (chemistry)
Tetrahedrons
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Description
Summary:The synthesis and characterization of highly challenging 2,3,6-trideoxy sugar nucleotides were described for the first time. The study of their hydrolysis kinetics in aqueous buffers provided insight into their application as glycosyl donors.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.08.132