Amphidinin G, a putative biosynthetic precursor of amphidinin A from marine dinoflagellate Amphidinium sp

[Display omitted] A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and the stereochemistry was elucidated by the combination of J-value analysis, modified Mosh...

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Bibliographic Details
Published in:Tetrahedron letters 2015-02, Vol.56 (8), p.990-993
Main Authors: Kubota, Takaaki, Iwai, Takahiro, Ishiyama, Haruaki, Sakai, Kanae, Gonoi, Tohru, Kobayashi, Jun’ichi
Format: Article
Language:English
Subjects:
Amphidinium
Amphidinium sp
Antifungal
Biosynthetic precursor
Dinoflagellate
Dinoflagellates
Linear polyketide
Marine
Nuclear magnetic resonance
Planar structures
Precursors
Stereochemistry
Tetrahedrons
Trichophyton mentagrophytes
Two dimensional
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Summary:[Display omitted] A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and the stereochemistry was elucidated by the combination of J-value analysis, modified Mosher’s method, and NMR chemical shift comparison with synthetic analogues. Amphidinin G (1) was expected to be a biosynthetic precursor of amphidinin A (2), a known linear dinoflagellate polyketide. Amphidinin G (1) showed antifungal activity against Trichophyton mentagrophytes.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.01.058