A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

A novel three linear step synthesis of Celecoxib was achieved in 33% overall yield via a key regioselective direct C–H arylation reaction between a 1,3-disubstituted pyrazole and an aryl bromide.

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2011-11, Vol.52 (45), p.6000-6002
Main Authors: Gaulier, Steven M., McKay, Reuben, Swain, Nigel A.
Format: Article
Language:English
Subjects:
Aromatic compounds
Bromides
Celecoxib
Chemistry
Direct arylation
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Pd catalysis
Preparations and properties
Pyrazole
Synthesis (chemistry)
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel three linear step synthesis of Celecoxib was achieved in 33% overall yield via a key regioselective direct C–H arylation reaction between a 1,3-disubstituted pyrazole and an aryl bromide.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.08.174