A facile ultrasonication assisted method for Fe sub(3)O sub(4)SiO sub(2 )-Ag nanospheres with excellent antibacterial activity

To increase the monodispersity of magnetic hybrid nanocomposites, a novel ultrasonic method was introduced to synthesize uniform Fe sub(3)O sub(4)SiO sub(2 )-Ag nanospheres. The immobilized Ag nanocrystals were tunable by varying the experimental conditions. An antibacterial assay indicated that the...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2015-05, Vol.44 (19), p.9140-9148
Main Authors: Chen, Shuang-Sheng, Xu, Hui, Xu, Hua-Jian, Yu, Guang-Jin, Gong, Xing-Long, Fang, Qun-Ling, Leung, Ken Cham-Fai, Xuan, Shou-Hu, Xiong, Qi-Ru
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Assaying
Bacteria
Escherichia coli
Human
Nanocomposites
Nanocrystals
Nanospheres
Staphylococcus
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Summary:To increase the monodispersity of magnetic hybrid nanocomposites, a novel ultrasonic method was introduced to synthesize uniform Fe sub(3)O sub(4)SiO sub(2 )-Ag nanospheres. The immobilized Ag nanocrystals were tunable by varying the experimental conditions. An antibacterial assay indicated that the Fe sub(3)O sub(4)SiO sub(2 )-Ag nanospheres exhibited excellent antibacterial activities against Staphylococcus aureusand Escherichia coli, in which the minimum inhibition concentrations (MIC) were 40 mu g mL super(-1) and 20 mu g mL super(-1), respectively. The live/dead bacterial cell fluorescence stain assay agreed well with the antibacterial assay. The CCK-8 results indicated these nanospheres were bio-compatible for human normal cells and presented relative cytotoxicity against HepG2 tumor cells. These nanospheres could be easily uptaken by the cells and they could affect bacterial cells both inside and outside the cell membrane, which enable them to be promisingly applied in future biomedical areas.
ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt00977d