Two new furostanol glycosides from the fruits of Tribulus terrestris

Two new furostanol glycosides, named terrestrinones A1/A2 (1a/1b), were isolated from the fruits of Tribulus terrestris L. together with four known compounds, and their structures were determined by spectroscopic methods, including 2D NMR experiments. All of the isolates (1–5) were evaluated for the...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2013-07, Vol.54 (30), p.3967-3970
Main Authors: Hong, Seong Su, Choi, Yun-Hyeok, Jeong, Wonsik, Kwon, Jin Gwan, Kim, Jin Kyu, Seo, Changon, Ahn, Eun-Kyung, Lee, Hyun Hwa, Ko, Han-Jik, Seo, Dong-Wan, Oh, Joa Sub
Format: Article
Language:English
Subjects:
Fruits
Furostanol glycoside
Glycosides
Macrophages
Nitric oxide
Nitric oxide inhibitor
Nuclear magnetic resonance
Spectroscopy
Terrestrinone A1
Tetrahedrons
Tribulus terrestris
Two dimensional
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new furostanol glycosides, named terrestrinones A1/A2 (1a/1b), were isolated from the fruits of Tribulus terrestris L. together with four known compounds, and their structures were determined by spectroscopic methods, including 2D NMR experiments. All of the isolates (1–5) were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. Of these, compounds 2 and 3 inhibited nitric oxide production with IC50 values of 7.1 and 46.6μM.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.05.081