Synthesis of chiral [beta]-chalcogen amine derivatives and Gram-positive bacteria activity

Efficient ring opening reaction between aziridines and diphenyl dichalogenides using HCl, Zn degree in ionic liquid is disclosed, affording chiral [beta]-chalcogen amines derivatives in good yields under mild reaction condition. The ionic liquid was further reused four times without the loss of its...

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Bibliographic Details
Published in:Tetrahedron 2012-12, Vol.68 (51), p.10444-10448
Main Authors: Vargas, Josimar, Narayanaperumal, Senthil, Gul, Kashif, Ravanello, Bruno B, Dornelles, Luciano, Soares, Letiere C, Alves, Camilla FS, Schneider, Taiane, Vaucher, Rodrigo de A, Santos, Roberto CV, Rodrigues, Oscar ED
Format: Article
Language:English
Subjects:
Amines
Antiinfectives and antibacterials
Antimicrobial activity
Bacteria
Derivatives
Gram-positive bacteria
Ionic liquids
Ring opening
Strain
Tetrahedrons
Zinc
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Summary:Efficient ring opening reaction between aziridines and diphenyl dichalogenides using HCl, Zn degree in ionic liquid is disclosed, affording chiral [beta]-chalcogen amines derivatives in good yields under mild reaction condition. The ionic liquid was further reused four times without the loss of its efficiency. The chiral chalcogenoamines showed antimicrobial activity against Gram-positive bacteria strains.
ISSN:0040-4020
DOI:10.1016/j.tet.2012.09.049