Hyrtimomines, indole alkaloids from Okinawan marine sponges Hyrtios spp

Six new indole alkaloids, hyrtimomines F–K (1–6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1–6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an α-keto-ɛ-caprolactam ring, while hyrtimo...

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Bibliographic Details
Published in:Tetrahedron 2014-01, Vol.70 (4), p.832-837
Main Authors: Tanaka, Naonobu, Momose, Rei, Takahashi-Nakaguchi, Azusa, Gonoi, Tohru, Fromont, Jane, Kobayashi, Jun'ichi
Format: Article
Language:English
Subjects:
Alkaloids
Antiinfectives and antibacterials
Hyrtimomines
Hyrtios
Hyrtios spp
Indole alkaloids
Indoles
Marine
Marine sponge
Spectroscopic analysis
Sponges
Tetrahedrons
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Summary:Six new indole alkaloids, hyrtimomines F–K (1–6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1–6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an α-keto-ɛ-caprolactam ring, while hyrtimomine G (2) is a symmetrical bisindole alkaloid. Hyrtimomines H–K (3–6) are indole alkaloids possessing β-carboline skeleton with an imidazolium unit. Antimicrobial activities of hyrtimomines F–K (1–6) were evaluated. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.12.032