Novel Broensted acidic deep eutectic solvent as reaction media for esterification of carboxylic acid with alcohols

New halogen-free Broensted acidic deep eutectic solvents (DES) have been prepared by mixing new quaternary ammonium methanesulfonate salts with p-toluenesulfonic acid (PTSA). They have been used as dual solvent-catalyst for esterification of several carboxylic acids with different alcohols with a re...

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Bibliographic Details
Published in:Tetrahedron letters 2012-09, Vol.53 (38), p.5151-5155
Main Authors: De Santi, Valerio, Cardellini, Fabio, Brinchi, Lucia, Germani, Raimondo
Format: Article
Language:English
Subjects:
Alcohols
Carboxylic acids
Esterification
Esters
Eutectic reactions
Eutectics
Solvents
Tetrahedrons
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Summary:New halogen-free Broensted acidic deep eutectic solvents (DES) have been prepared by mixing new quaternary ammonium methanesulfonate salts with p-toluenesulfonic acid (PTSA). They have been used as dual solvent-catalyst for esterification of several carboxylic acids with different alcohols with a reagent molar ratio of 1: 1. The method is mild, safe, and simple. Ease of recovery and reusability of DES with high activity makes this method efficient and eco-friendly. The tunability of DES properties, attained by changes in the cation, was performed in order to achieve various esters in good yields.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2012.07.063