Synthetic trehalose di- and mono-esters of α-, methoxy- and keto-mycolic acids

Synthetic mycolic acids matching the overall structure of the major mycolic acids of Mycobacterium tuberculosis are coupled to trehalose to generate the corresponding synthetic trehalose monomycolate (TMM) and trehalose dimycolate (TDM; cord factor), either with two identical or two different mycoli...

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Bibliographic Details
Published in:Tetrahedron 2014-12, Vol.70 (52), p.9836-9852
Main Authors: Al Dulayymi, Juma'a R., Baird, Mark S., Maza-Iglesias, Maximiliano, Hameed, Rwoa'a T., Baols, Klarah S., Muzael, Majed, Saleh, Ahmed D.
Format: Article
Language:English
Subjects:
Joining
Matching
Rope
Synthesis
TDM
Tetrahedrons
Time division multiplexing
TMM
Trehalose
Trehalose dimycolates
Trehalose monomycolates
Tuberculosis
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Summary:Synthetic mycolic acids matching the overall structure of the major mycolic acids of Mycobacterium tuberculosis are coupled to trehalose to generate the corresponding synthetic trehalose monomycolate (TMM) and trehalose dimycolate (TDM; cord factor), either with two identical or two different mycolic acids. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.10.072