Bioinspired Mechanism for the Translocation of Peptide through the Cell Membrane

Discreetness of a cell is the key to life, with the cell membrane separating the interior cytosol from its environment. In this regard, cytosol is never connected to the external media even during the course of cell fission or fusion. However, water-soluble peptides called protein transduction domai...

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Bibliographic Details
Published in:Chemistry letters 2012-10, Vol.41 (10), p.1078-1080
Main Authors: Sakamoto, Kazutami, Aburai, Kenichi, Morishita, Taku, Sakai, Kenichi, Sakai, Hideki, Abe, Masahiko, Nakase, Ikuhiko, Futaki, Shiroh
Format: Article
Language:English
Subjects:
Membrane structures
Membranes
Peptides
PTD
Receptors
Temporal logic
Transformations
Transporter
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Summary:Discreetness of a cell is the key to life, with the cell membrane separating the interior cytosol from its environment. In this regard, cytosol is never connected to the external media even during the course of cell fission or fusion. However, water-soluble peptides called protein transduction domain (PTD) can spontaneously translocate through the cell membranes without any particular transporter or receptor. Here, we propose that the translocation of PTD can be described based on a local and temporal dynamic topological transformation of the membrane structure to mesh phase.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2012.1078