Efficient synthesis of diversely substituted pyrimidines by palladium catalyzed Suzuki–Miyaura coupling

An efficient synthesis of 2-aryl/heteroaryl substituted pyrimidinyl ethanones 4(a–t) was developed using a palladium-catalyzed Suzuki–Miyaura coupling reaction strategy. Use of Pd(OAc)2 in the presence of PPh3 and Na2CO3 in 1,4-dioxane solvent was found to be the most effective reaction condition....

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Bibliographic Details
Published in:Tetrahedron letters 2014-02, Vol.55 (8), p.1456-1460
Main Authors: Faldu, Viral J., Talpara, Pratik K., Shah, Viresh H.
Format: Article
Language:English
Subjects:
Chemical reactions
Joining
Palladium
Palladium catalyst
Pyrimidines
Solvents
Strategy
Suzuki–Miyaura coupling
Synthesis (chemistry)
Tetrahedrons
Triphenylphosphine
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Summary:An efficient synthesis of 2-aryl/heteroaryl substituted pyrimidinyl ethanones 4(a–t) was developed using a palladium-catalyzed Suzuki–Miyaura coupling reaction strategy. Use of Pd(OAc)2 in the presence of PPh3 and Na2CO3 in 1,4-dioxane solvent was found to be the most effective reaction condition.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.01.042