A facile microwave assisted synthesis of spiro-1,3-oxazines from N-(2-(cyclohex-1-en-1-yl)ethyl)amides

A mild and efficient methodology has been developed for the synthesis of spiro-1,3-oxazine derivatives by the microwave assisted cyclization of N-2-(1′-cyclohexenyl)ethyl-acetamides/benzamides. The reaction was catalyzed by in situ generated trimethylsilyl iodide and featured by its very short react...

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Bibliographic Details
Published in:Tetrahedron letters 2014-07, Vol.55 (31), p.4328-4330
Main Authors: Saikia, Ujwal Pratim, Baruah, Diganta, Pahari, Pallab, Borah, Manash Jyoti, Goswami, Amrit, Konwar, Dilip
Format: Article
Language:English
Subjects:
Amines
Benzamide
Condensing
Derivatives
Iodides
Microwave assisted synthesis
Microwaves
Spiroxazine
Synthesis (chemistry)
Tetrahedrons
Trimethylsilyl iodide
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Summary:A mild and efficient methodology has been developed for the synthesis of spiro-1,3-oxazine derivatives by the microwave assisted cyclization of N-2-(1′-cyclohexenyl)ethyl-acetamides/benzamides. The reaction was catalyzed by in situ generated trimethylsilyl iodide and featured by its very short reaction time. The starting materials were easily obtained by the condensation of substituted acetic/benzoic acids with 2-(1′-cyclohexenyl)ethyl amine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.06.042