Polyketides from the mangrove-derived endophytic fungus Acremonium strictum

Five new polyketide derivatives, 6′-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6–12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhiz...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2014-06, Vol.55 (24), p.3463-3468
Main Authors: Hammerschmidt, Lena, Debbab, Abdessamad, Ngoc, Tu Duong, Wray, Victor, Hemphil, Catalina Perèz, Lin, WenHan, Broetz-Oesterhelt, Heike, Kassack, Matthias U., Proksch, Peter, Aly, Amal H.
Format: Article
Language:English
Subjects:
Acremonium
Acremonium strictum
Antiinfectives and antibacterials
Biotechnology
Cytotoxic activity
Derivatives
Endophytic fungus
Fungi
Human
Mangrove trees
Polyketides
Rhizophora apiculata
Staphylococcus aureus
Tetrahedrons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five new polyketide derivatives, 6′-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6–12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhizophora apiculata. The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6, 7, and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC50 values 27.1, 76.2, and 8.3μM, respectively) and resistant A2780 cell lines (IC50 values 12.6, 30.1, and 19.0μM, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3μM).
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.04.063