A facile one-pot synthesis of 7-substituted pyrazolo[1,5-a]pyrimidines by base induced three-component reaction

The preparation of steroid/nonsteroid fused 7-substituted pyrazolo[1,5-a]pyrimidines is described by a one-pot reaction of steroidal/nonsteroidal ketones, aromatic aldehydes and 3-amino-1H-pyrazoles/5-amino-1H-pyrazoles in the presence of potassium tert-butoxide in good yield under reflux condition...

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Bibliographic Details
Published in:Tetrahedron letters 2014-07, Vol.55 (29), p.3896-3900
Main Authors: Saikia, Pallabi, Kaishap, Partha Pratim, Prakash, Rashmi, Shekarrao, Kommuri, Gogoi, Sanjib, Boruah, Romesh C.
Format: Article
Language:English
Subjects:
Aldehydes
Amino-1H-pyrazole
Ethanol
Ethyl alcohol
Heterocycle
Ketones
Potassium
Potassium tert-butoxide
Pyrazolo[1,5-a]pyrimidine
Steroid
Steroids
Synthesis (chemistry)
Tetrahedrons
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Summary:The preparation of steroid/nonsteroid fused 7-substituted pyrazolo[1,5-a]pyrimidines is described by a one-pot reaction of steroidal/nonsteroidal ketones, aromatic aldehydes and 3-amino-1H-pyrazoles/5-amino-1H-pyrazoles in the presence of potassium tert-butoxide in good yield under reflux condition in ethanol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.05.021